Ligand-free nickel-catalyzed C-S bond formation: synthesis of 2-aminobenzothiazoles
نویسندگان
چکیده
A Ni-catalyzed C-S bond forming reaction has been developed for the synthesis of 2-aminobenzothiazole by the coupling of 2-haloanilines (-bromo and -iodo) with isothiocyanates. The key advantages of this procedure are ligand-free condition, inexpensive catalyst, high yields, and simple purification of the products by nonchromatographic technique.
منابع مشابه
Copper-catalyzed synthesis of 2-aminobenzothiazoles from 2-iodophenyl isocyanides, potassium sulfide and amines.
A simple and practically useful synthetic method for the synthesis of a variety of 2-aminobenzothiazoles was developed. This methodology could construct one C-N bond and two C-S bonds in a step reaction and provide the desired products in good to perfect yields.
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